It migrates in beta 2 region on electrophoresis and has a molecular weight of 11. Beta2 microglobulin b2m is a protein shed by cells into the blood, including tumor cells. Despite its potential role as a convenient and noninvasive prognostic indicator in malignant lymphomas. Beta 2 microglobulin an overview sciencedirect topics.
Background dialysisrelated destructive spondyloarthropathy caused by beta 2 microglobulin. Beta 2 microglobulin, a lowmolecularweight protein associated with the. Useful for prognosis evaluation of multiple myeloma and for evaluation of renal. Pdf circulating beta2microglobulin b2m looks like the exptession oi turnover oi cell membranes with nucleus sinceit is the light chain oi hla. Figure out the severity of cancer and whether it has spread. The small size allows beta 2 m to pass through the glomerular membrane, but it is almost completely reabsorbed in the proximal tubules. Beta2microglobulin concentration reported in mcgml. Recombinant human beta 2 microglobulin protein ab98116. Beta2microglobulin beta 2 m is a small membrane protein 11,800 dalton associated with the heavy chains of class i major histocompatibility complex proteins and is, therefore, on the surface of all nucleated cells. Recombinant human beta 2 microglobulin protein is an escherichia coli full length protein 21 to 119 aa range, 95% purity and validated in sdspage, ms. Search results for beta 2 microglobulin at sigmaaldrich. Pdf comportamento della beta2microglobulina in alcune.
A beta 2 microglobulin tumor marker test is most often given to people who have been diagnosed with certain cancers of the bone marrow or blood. A beta2 microglobulin b2m tumor marker test measures the amount of b2m in the blood, urine, or cerebrospinal fluid. Serum beta 2 microglobulin and angiotensinconverting enzyme activity in sarcoidosis. Beta2 microglobulin is synthesized in all nucleated cells and forms the light chain subunit of the major histocompatibility complex class i antigen. A local inflammatory reaction to beta 2 microglobulin beta 2 m amyloid deposits by monocytesmacrophages is a characteristic histologic feature of dialysisrelated amyloidosis dra. Renal handling of beta2microglobulin in the human neonate.
The implication and significance of beta 2 microglobulin. It is homologous to ch 3 domain of human immunoglobulin. Renal handling of beta 2 microglobulin in the human neonate william d. Beta2 microglobulin levels in hemodialysis patients. Pdf serum beta2microglobulin and angiotensinconverting. Beta2 microglobulina marcador tumoral lab tests onlinees. The higher the stage, the more advanced the cancer is.
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